Protease gene structure and env gene variability of the AIDS virus |
| |
Authors: | T Yasunaga N Sagata Y Ikawa |
| |
Institution: | 1. Computation Center and Laboratory of Molecular Oncology, The Institute of Physical and Chemical Research, Wako,Saitama 351-01, Japan |
| |
Abstract: | The protease gene structure and the env gene variability have been precisely compared between the AIDS virus and members of the HTLV/BLV family. The conserved amino acid sequence (LVDT) which is repeated in the proteases of the HTLV/BLV family is not repeated in AIDS virus. Comparative analysis of the env gene sequences reveals the striking fact that the env gene of AIDS virus is 8-12-times more variable than those of the HTLV/BLV family. Within the AIDS virus env gene, the surface glycoprotein region is more liable to vary than is the transmembrane region; unexpectedly, however, this liability is not a characteristic feature of the AIDS virus because it is more prominent in other retroviruses including members of the HTLV/BLV family. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|