Light damaging action of all-<Emphasis Type="Italic">trans</Emphasis>-retinal and its derivatives on rhodopsin molecules in the photoreceptor membrane |
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Authors: | M Yu Loginova Ye V Rostovtseva T B Feldman M A Ostrovsky |
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Institution: | (1) Emanuel’ Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, 119334 Moscow, Russia |
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Abstract: | We have reproduced the model system containing A2-rhodopsin, NR-PE, A2-PE, and ATR-dimer-PE in order to study photosensitized damage of rhodopsin within photoreceptor membranes of rod outer segments. We have demonstrated that irradiation of such a system with visible light (400-700 nm) distorts the most important functional property of native visual pigment--its ability to regenerate after addition of 11-cis-retinal in the dark. We have also shown that all-trans-retinal bound to membrane phospholipids and rhodopsin has less photosensitizing activity that free all-trans-retinal. |
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Keywords: | visual pigment rhodopsin all-trans-retinal photosensitizers photodamage |
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