Familial monozygotic twinning: report of an extended multi-generation family. |
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| Authors: | Hanan A Hamamy Heitham K Ajlouni Kamel M Ajlouni |
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| Institution: | National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan. |
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| Abstract: | Thirteen sets of monozygotic (MZ) twins from an extended multi-generation family are reported. Zygosity was determined by interviewing families for overall physical similarity and by assessment of facial photographs. A hypothetical gene was traced back five generations to a common grandfather. Familial monozygotic twinning in this pedigree is compatible with autosomal dominant inheritance with reduced penetrance. Other plausible mechanisms of inheritance are discussed. |
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