Genomic organisation and alternative splicing of mouse and human thioredoxin reductase 1 genes |
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Authors: | Simone A Osborne Kathryn F Tonissen |
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Affiliation: | (1) School of Biomolecular and Biomedical Science, Griffith University, 4111 Nathan, Queensland, Australia |
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Abstract: | Background Thioredoxin reductase (TR) is a redox active protein involved in many cellular processes as part of the thioredoxin system. Presently there are three recognised forms of mammalian thioredoxin reductase designated as TR1, TR3 and TGR, that represent the cytosolic, mitochondrial and novel forms respectively. In this study we elucidated the genomic organisation of the mouse (Txnrd1) and human thioredoxin reductase 1 genes (TXNRD1) through library screening, restriction mapping and database mining. |
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