Spatial partitioning of secretory cargo from Golgi resident proteins in live cells |
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Authors: | Jamie White Patrick Keller Ernst HK Stelzer |
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Institution: | (1) European Molecular Biology Laboratory(EMBL), Light Microscopy Group, Meyerhofstrabe Heidelberg, Germany;(2) Cell Biology and Biophysics Programme European Molecular Biology Laboratory (EMBL) Meyerhofstraβe, , Heidelberg, Germany;(3) Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraβe 108, Dresden, Germany;(4) Massachusetts General Hospital Cancer Research Center, Charlestown, Massachusetts, USA |
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Abstract: | Background To maintain organelle integrity, resident proteins must segregate from itinerant cargo during secretory transport. However,
Golgi resident enzymes must have intimate access to secretory cargo in order to carry out glycosylation reactions. The amount
of cargo and associated membrane may be significant compared to the amount of Golgi membrane and resident protein, but upon
Golgi exit, cargo and resident are efficiently sorted. How this occurs in live cells is not known. |
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Keywords: | |
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