5-Hydroxytryptamine and (+)-lysergic acid diethylamide displace [3H]thyrotropin-releasing hormone at its binding sites in the rat limbic forebrain |
| |
Authors: | S Teshima K Funatsu H Satoh K Inanaga |
| |
Affiliation: | 1. The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong, PR China;2. Guangdong Key Lab of Orthopedic Technology and Implant Materials, General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, Guangdong, PR China;3. Department of Trauma Orthopedics, General Hospital of Southern Theatre Command of PLA, Guangzhou 510010, Guangdong, PR China;4. Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang 330006, Jiangxi, PR China;1. Department of Psychology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany;2. Department of Psychology, University of Augsburg, Germany |
| |
Abstract: | Binding of [3H]thyrotropin-releasing hormone (TRH) to its receptors in the rat limbic forebrain was partially displaced by 5-hydroxytryptamine (5-HT, ligand for 5-HT1 receptors) and (+)-lysergic acid diethylamide ((+)-LSD, ligand for 5-HT1 and 5-HT2 receptors) at nanomolar concentrations. Spiperone (ligand for 5-HT2 receptors) displaced [3H]TRH in a dose-dependent manner at micromolar concentrations. These results suggest that some TRH receptors are related to 5-HT1 receptors, probably adjoining them on the membrane. This type of TRH receptor is shown to be among the high-affinity receptors which we reported previously. The significance of the receptor-coexistence is such that TRH facilitates serotonergic transmission by increasing the density of 5-HT1 receptors. This finding seems to support a pharmacological observation of other investigators that TRH potentiates 5-HT-induced hyperactivity in mice, probably by affecting postsynaptic 5-HT receptors. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|