间充质干细胞分化为内皮细胞的意义和细胞学基础

间充质干细胞(mesenchymalstemcells,MSCs)主要存在于骨髓中,是多潜能干细胞,在脐血、外周血、脂肪、皮肤等多种组织中也相继分离出MSCs。MSCs具有独特的免疫特性,在异种异体环境内长期存在,使其临床应用前景更为广泛。目前,MSCs的分离培养、诱导分化及鉴定体系已趋成熟,理论上可分化为所有中胚层来源的细胞,内皮细胞来源于中胚层,因此MSCs具有分化为内皮细胞的可能性。本文对MSCs内皮分化意义和细胞学基础及其新近的研究进展作一综述。

Cytological basis and significance of mesenchymal stem cells differentiated into endothelial cells

Mesenchymal stem cells (MSCs) are a multipotent population which mainly localized in the bone marrow. MSCs were also isolated from the umbilical blood, peripheral blood, fatty tissue, skin and so on. MSCs have special immunity and persist in the xenogeneic explantation which expand the clinical application. At present, the system of culturation, induction and identification of MSCs are gradually becoming mature. Meanwhile, MSCs differentiate into cells derived from mesoderm in the theory. Endothelial cells derived from the mesoderm, MSCs have potency of differentiated into endothelial cells(ECs).This review focuses on the significance and cytological basis of human MSCs differentiate into endothelial cells, as well as the recent advancement and application on the tissue engineering.