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PRMT5 inhibition induces pro-inflammatory macrophage polarization and increased hepatic triglyceride levels without affecting atherosclerosis in mice |
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| Authors: | Yiheng Zhang Robin A F Verwilligen Miranda Van Eck Menno Hoekstra |
| Institution: | 1. Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands
Contribution: Conceptualization (equal), Data curation (equal), Formal analysis (equal), Investigation (equal), Validation (equal), Visualization (equal), Writing - original draft (equal);2. Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands Pharmacy Leiden, Leiden, The Netherlands Contribution: Funding acquisition (lead), Project administration (equal), Supervision (equal), Writing - review & editing (equal);3. Division of BioTherapeutics, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands |
| Abstract: | |
| Keywords: | atherosclerosis fatty liver disease inflammation macrophages protein arginine methyltransferase 5 |