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Newly discovered mechanisms that mediate tumorigenesis and tumour progression: circRNA-encoded proteins |
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| Authors: | Chengwei Wu Song Wang Tingting Cao Tao Huang Lishuai Xu Jiawei Wang Qian Li Ye Wang Long Qian Li Xu Yabin Xia Xiaoxu Huang |
| Institution: | 1. Department of Gastrointestinal Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, China
Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution, Wannan Medical College, Wuhu, China Contribution: Conceptualization (equal), Writing - original draft (equal);2. Department of Thoracic Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, China Contribution: Conceptualization (equal), Writing - original draft (equal);3. Department of Gastrointestinal Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, China Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution, Wannan Medical College, Wuhu, China Contribution: Writing - review & editing (equal);4. The Second Affiliated Hospital of Wannan Medical College, Wuhu, China Contribution: Writing - review & editing (equal);5. Department of Gastrointestinal Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, China Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution, Wannan Medical College, Wuhu, China Contribution: Conceptualization (equal), Supervision (equal), Writing - review & editing (equal);6. Department of Gastrointestinal Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, China |
| Abstract: | Proteins produced by cap-independent translation mediated by an internal ribosome entry site (IRES) in circular RNAs (circRNAs) play important roles in tumour progression. To date, numerous studies have been performed on circRNAs and the proteins they encode. In this review, we summarize the biogenesis of circRNAs and the mechanisms regulating circRNA-encoded proteins expression. We also describe relevant research methods and their applications to biological processes such as tumour cell proliferation, metastasis, epithelial-mesenchymal transition (EMT), apoptosis, autophagy and chemoresistance. This paper offers deeper insights into the roles that circRNA-encoded proteins play in tumours. It also provides a theoretical basis for the use of circRNA-encoded proteins as biomarkers of tumorigenesis and for the development of new targets for tumour therapy. |
| Keywords: | circRNA circRNA-encoded protein research methods translational medicine tumour malignancy progression |