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WHSC1 is involved in DNA damage,cellular senescence and immune response in hepatocellular carcinoma progression |
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| Authors: | Jia Yan Ming Yang Zhang Jing Lin Ke Xin Li Zhi Min Zhao Yu Min Gao Xiu Ling Deng Chang Shan Wang Hai Sheng Wang |
| Affiliation: | 1. School of Basic medical, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China;2. School of Life science, Inner Mongolia University, Hohhot, Inner Mongolia, China Contribution: Data curation (lead), Methodology (lead), Supervision (lead);3. School of Life science, Inner Mongolia University, Hohhot, Inner Mongolia, China Department of Nutrition, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China Contribution: Data curation (equal), Investigation (equal), Methodology (equal), Resources (equal), Software (equal), Supervision (equal);4. School of Life science, Inner Mongolia University, Hohhot, Inner Mongolia, China Contribution: Data curation (equal), Formal analysis (equal), Resources (equal), Software (equal);5. School of Life science, Inner Mongolia University, Hohhot, Inner Mongolia, China Contribution: Data curation (equal), Formal analysis (equal), Investigation (equal), Methodology (equal), Visualization (equal);6. School of Public health, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China Contribution: Data curation (lead), Project administration (equal), Supervision (equal), Validation (equal);7. School of Life science, Inner Mongolia University, Hohhot, Inner Mongolia, China |
| Abstract: | Wolf–Hirschhorn syndrome candidate 1 (WHSC1) is a transcriptional regulatory protein that encodes a histone methyltransferase to control H3K36me2 modification. WHSC1 was upregulated and associated with poor prognosis in HCC. The elevated WHSC1 likely due to the alterations of DNA methylation or RNA modification. WHSC1 perhaps form a chromatin cross talk with H3K27me3 and DNA methylation to regulate transcription factors expression in HCC. Functional analysis indicated that WHSC1 was involved in DNA damage repair, cell cycle, cellular senescence and immune regulations. Furthermore, WHSC1 was associated with the infiltrating levels of B cell, CD4+, Tregs and macrophage cells. Therefore, our findings suggested that WHSC1 might function as a promotor regulator to affect the development and progression of HCC. Thus, WHSC1 could be a potential biomarker in predicting the prognosis and therapeutic target for patients with HCC. |
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