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Flotillin-1 is a prognostic biomarker for glioblastoma and promotes cancer development through enhancing invasion and altering tumour microenvironment |
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| Authors: | Ran Wang Zhikang Chen Yi Zhang Shihan Xiao Wuming Zhang Xianqin Hu Qun Xiao Qing Liu Xiangyu Wang |
| Institution: | 1. Department of Colorectal and Anus Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China;2. Department of Colorectal and Anus Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha, Hunan, China Contribution: Conceptualization (equal), Funding acquisition (equal), Project administration (equal), Supervision (equal), Writing - review & editing (equal);3. Department of Neurosurgery, Dengzhou People's Hospital, Dengzhou, Henan, China Contribution: Data curation (equal), Funding acquisition (equal), Resources (equal), Writing - review & editing (equal);4. Department of Colorectal and Anus Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China Contribution: Data curation (equal), Formal analysis (equal), Resources (equal), Writing - review & editing (equal);5. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China Contribution: Data curation (equal), Methodology (equal), Resources (equal), Software (equal), Visualization (equal), Writing - review & editing (equal);6. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China |
| Abstract: | Flotillin-1(FLOT1) has long been recognized as a tumour-promoting gene in several types of cancer. However, the expression and function of FLOT1 in glioblastomas (GBM) has not been elucidated. Here, in this study, we find that the expression level of FLOT1 in GBM tissue was much higher than that in normal brain, and the expression was even higher in the more aggressive subtypes and IDH status of glioma. Kaplan–Meier survival revealed that high FLOT1 expression is closely associated with poor outcome in GBM patients. FLOT1 knockdown markedly reduced the proliferation, migration and invasiveness of GBM cells, while FLOT1 overexpression significantly increases GBM cell proliferation, migration and invasiveness. Mechanistically, FLOT1 expression may play a potential role in the microenvironment of GBM. Therefore, FLOT1 promotes GBM proliferation and invasion in vitro and in vivo and may serve as a biomarker of prognosis and therapeutic potential in the fight against GBM. |
| Keywords: | flotillin-1 glioblastoma invasiveness prognostic biomarker tumour microenvironment |