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Potential impact of ADAM-10 genetic variants with the clinical features of oral squamous cell carcinoma |
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| Authors: | Yi-Tzu Chen Chiao-Wen Lin Ying-Erh Chou Shih-Chi Su Lun-Ching Chang Chia-Yi Lee Ming-Ju Hsieh Shun-Fa Yang |
| Affiliation: | 1. School of Dentistry, Chung Shan Medical University, Taichung, Taiwan Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan Contribution: Conceptualization (equal), Writing - original draft (equal), Writing - review & editing (equal);2. Department of Dentistry, Chung Shan Medical University Hospital, Taichung, Taiwan Institute of Oral Sciences, Chung Shan Medical University, Taichung, Taiwan Contribution: Writing - original draft (equal);3. School of Medicine, Chung Shan Medical University, Taichung, Taiwan Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan Contribution: Methodology (equal);4. Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan Contribution: Methodology (equal);5. Department of Mathematical Sciences, Florida Atlantic University, Boca Raton, Florida, USA Contribution: Methodology (equal);6. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan Nobel Eye Institute, Taipei, Taiwan Contribution: Writing - original draft (equal);7. Oral Cancer Research Center, Changhua Christian Hospital, Changhua, Taiwan;8. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan |
| Abstract: | A disintegrin and metalloproteinase domain-containing protein 10 (ADAM-10) involves in the tumour progression, but the impacts of single-nucleotide polymorphism (SNP) of ADAM-10 on oral squamous cell carcinoma (OSCC) remain unclear. The aim of this study was to investigate the influence of SNP of ADAM-10 on the clinical features of OSCC in male Taiwanese. Five loci of ADAM-10 SNPs including rs653765 (C/T), rs2305421 (A/G), rs514049 (A/C), rs383902 (T/C) and rs2054096 (A/T) were genotyped by TaqMan allelic discrimination in 1138 OSCC patients and 1199 non-OSCC individuals. The ADAM-10 SNP rs2305421 GG (AOR: 1.399, 95% CI: 1.045–1.874, p = 0.024) and G allele (AOR: 1.170, 95% CI: 1.012–1.351, p = 0.034) illustrated a significantly higher genotypic frequencies in the OSCC group compared to the distribution of the ADAM-10 SNP rs2305421 AA wild type. In the subgroup analysis, the ADAM-10 SNP rs383902 TC+CC was significantly correlated to tumour size larger than T2 in betel quid chewer (AOR: 1.375, 95% CI: 1.010–1.872, p = 0.043), while the ADAM-10 SNP rs653765 CT+TT was significantly associated with tumour size larger than T2 in cigarette smoker (AOR: 1.346, 95% CI: 1.023–1.772, p = 0.034). The results from The Cancer Genome Atlas revealed highest ADAM-10 mRNA level in T2 stage of current smokers with head and neck squamous cell carcinoma (HNSCC). In conclusions, the ADAM-10 SNP rs2305421 G allele is associated with the presence of OSCC, and the ADAM-10 SNP rs383902 TC+CC and ADAM-10 SNP rs653765 CT+TT correlates to large tumour size in specific conditions. |
| Keywords: | ADAM-10 betel quid cigarette oral squamous cell carcinoma single-nucleotide polymorphisms |