Selective estrogen-induced apoptosis in breast cancer |
| |
| Affiliation: | 1. Department of Surgery, University of Michigan School of Medicine, BSRB 5448, 109 Zina Pitcher Place, Ann Arbor, MI 48109-0669, USA;2. Department of Obstetrics and Gynecology, University of Michigan School of Medicine, L4604 WH, 1500 East Medical Center, Ann Arbor, MI 48109, USA;3. Department of Surgery, University of Michigan School of Medicine, BSRB 5071, 109 Zina Pitcher Place, Ann Arbor, MI 48109-0669, USA;1. Department of Rehabilitation Medicine, Amsterdam Movement Sciences and Emma Children''s Hospital, Amsterdam UMC, Vrije Universiteit, University of Amsterdam, Netherlands;1. Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary;2. Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary;3. Cereal Research Non-Profit LTD, P.O. Box 391, H-6701 Szeged, Hungary;4. Virtua Drug Ltd, Csalogány u. 4C, H-1015 Budapest, Hungary;1. Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030, Wuhan, China;2. Department of Nutrition and Food Hygiene and MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030, Wuhan, China;3. College of Life Science, Institute of Biomedicine, Yangtze University, Jingzhou, China;4. Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, Czech Republic;1. Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, China;2. Jiangnan University School of Medicine, Wuxi, China;3. Department of Oncology, Second People''s Hospital of Taizhou, Taizhou, China;1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China;2. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China;3. New Drug Research & Development Center, Zhengzhou University, Zhengzhou 450001, China |
| |
| Abstract: | Antihormone therapy remains the gold standard of care in the treatment of estrogen receptor (ER) positive breast cancer. However, development of acquired long term antihormone resistance exposes a vulnerability to estrogen that induces apoptosis. Laboratory and clinical studies indicate that successful therapy with estrogens is dependent on the duration of estrogen withdrawal and menopausal status of a woman. Interrogation of estradiol (E2) induced apoptosis using molecular studies indicate treatment of long term estrogen deprived MCF-7 breast cancer cells with estrogen causes an endoplasmic reticulum stress response that induces an unfolded protein response signal to inhibit protein translation. E2 binds to the ER and mediates apoptosis through the classical genomic pathway. Furthermore, the induction of apoptosis by estrogens is dependent on the conformation of the estrogen–ER complex. In this review, we explore the mechanism and the processes involved in the paradox of estrogen induced apoptosis and the new selectivity of estrogen action on different cell populations that is correctly been deciphered for clinical practice. |
| |
| Keywords: | Estradiol Apoptosis Inflammation Unfolded protein response Endoplasmicreticulum stress Breast cancer |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
