Human lysyl oxidase-like 2 |
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| Institution: | 1. Programa de Recerca en Càncer, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), 08003 Barcelona, Spain;2. Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain;3. From the Institute of Sports Medicine Copenhagen and Center for Healthy Ageing, University of Copenhagen, DK-2400 Copenhagen, Denmark,;4. Section for Experimental Animal Models, Laboratory of Immunology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-1870 Frederiksberg, Denmark,;5. Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington 98195-6500, and;6. Wellcome Trust Center for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom;1. TargetEx Ltd., Madách Imre utca 31/2, H-2120 Dunakeszi, Hungary;2. Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary;3. Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/C, H-1117 Budapest, Hungary |
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| Abstract: | Lysyl oxidase like-2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises Cu2+- and lysine tyrosylquinone (LTQ)-dependent amine oxidases. LOXL2 is proposed to function similarly to LOX in the extracellular matrix (ECM) by promoting crosslinking of collagen and elastin. LOXL2 has also been proposed to regulate extracellular and intracellular cell signaling pathways. Dysregulation of LOXL2 has been linked to many diseases, including cancer, pro-oncogenic angiogenesis, fibrosis and heart diseases. In this review, we will give an overview of the current understandings and hypotheses regarding the molecular functions of LOXL2. |
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| Keywords: | Lysyl oxidase family Lysyl oxidase like-2 Lysine tyrosylquinone (LTQ) Cell signaling Extracellular matrix Tumor metastasis/invasion |
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