Design,synthesis and biological evaluation of novel thiosemicarbazide analogues as potent anticonvulsant agents |
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| Affiliation: | 1. Laboratory of Green Chemistry, Lappeenranta University of Technology, Sammonkatu 12, FI-50130 Mikkeli, Finland;2. Department of Chemistry, Laboratories of Inorganic and Analytical Chemistry, P.O. Box 35, FI-40014 University of Jyväskylä, Finland;3. Water & Environmental Technology (WET) Center, Department of Civil and Environmental Engineering, Temple University, Philadelphia, PA 19122, USA;4. Department of Chemistry, Laboratory of Organic Chemistry, P.O. Box 35, FI-40014 University of Jyväskylä, Finland;1. Department of Chemistry, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur 495009, Chhattisgarh, India;2. Department of Chemistry, The University of South Dakota, 414 E. Clark Street, Vermillion, SD 57069, USA;1. Department of Environmental Science, University of Kalyani, Kalyani, Nadia 741235, West Bengal, India;2. Institute of Physics, University of Neuchâtel, rue Emile-Argand 11, CH–2000 Neuchâtel, Switzerland;1. Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan;2. Departament de Química, Universitat de les Illes Balears, Crta. de Valldemossa km 7.5, 07122, Palma de Mallorca, Baleares, Spain;3. Department of Physics, University of Sargodha, Sargodha, 40100, Pakistan;4. Department of Chemistry, University of Otago, P.O. Box 56, Dunedin, 9054, New Zealand;1. Department of Chemistry, Banaras Hindu University, Varanasi 221005, India;2. Department of Chemical Sciences, Indian Institute of Science Education and Research, Mohali 140306, India;3. Department of Chemistry, Kirori Mal College, University of Delhi, Delhi-110007, India;1. Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221005, India;2. Department of Chemistry, Indian Institute of Technology, Kanpur 208016, India;3. Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD UK |
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| Abstract: | Novel thiosemicarbazide derivatives were synthesised and evaluated for their anticonvulsant activity and neurotoxicity. Anticonvulsant activity was done for grand mal and petit mal types of epilepsies by maximal electroshock (MES) and pentylenetetrazol (PTZ) induced convulsions methods respectively. Rotarod test was done to determine neurotoxicity. Amongst synthesised compounds, N-(4-bromophenyl)2-[(2-phenylhydrazinyl) carbonothioyl] hydrazinecarbothioamide (5e) is a broad-spectrum anticonvulsant agent since it was active in both (MES) and (PTZ) induced seizure models with no neurotoxicity and N,N-(bis(chlorophenyl)hydrazine-1,2-dicarbothoamide (5g) acts as a selective agent for grand mal epilepsy. |
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| Keywords: | Epilepsy Neurotoxicity Grand mal Petit mal |
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