Pattern of cardiac fibrosis in rabbits periodically fed a magnesium-restricted diet and administered rare earth chloride through drinking water |
| |
Authors: | C C Kartha J T Eapen C Radhakumary V Raman Kutty K Ramani A V Lal |
| |
Institution: | (1) Division of Cellular & Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences & Technology, 695011 Trivandrum, India;(2) Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences & Technology, 695011 Trivandrum, India;(3) Vivarium, Sree Chitra Tirunal Institute for Medical Sciences & Technology, 695011 Trivandrum, India |
| |
Abstract: | It has been postulated that causation of the tropical cardiomyopathy endomyocardial fibrosis (EMF) is linked to magnesium
(Mg) deficiency and cardiac toxicity of the rare earth element cerium (Ce). The aim of the present study was to define the
myocardial lesions in rabbits that were fed on Mg-restricted diet (70–80 ppm) periodically and were provided drinking water
contaminated with rare earth chloride (1 g/L). Forty New Zealand white rabbits were divided into four groups following a 2
× 2 factorial design. Two groups were periodically fed on Mg-restricted diet with one of them receiving water contaminated
with rare earth chloride. The other two groups were continuously fed on Mgsufficient diet (350–400 ppm) with one of them receiving
water contaminated with rare earth chloride. All animals were sacrificed at the end of 6 mo. Cardiac tissues were subjected
to histology, elemental analysis (calcium Ca], Mg, and Ce) and estimation of collagen content and collagen phenotypes. Histological
lesions were compared with those of EMF in humans and those of acute Mg deficiency in animals. The results suggest that in
rabbits, recurrent episodes of Mg deficiency lead to myocardial fibrosis similar to the pattern observed in human EMF. |
| |
Keywords: | Endomyocardial fibrosis cardiomyopathy magnesium lanthanides |
本文献已被 SpringerLink 等数据库收录! |
|