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Leptomeningeal disease in melanoma patients: An update to treatment,challenges, and future directions
Authors:Isabella C Glitza  Keiran S M Smalley  Priscilla K Brastianos  Michael A Davies  Ian McCutcheon  James K C Liu  Kamran A Ahmed  John A Arrington  Brittany R Evernden  Inna Smalley  Zeynep Eroglu  Nikhil Khushalani  Kim Margolin  Harriet Kluger  Michael B Atkins  Hussein Tawbi  Adrienne Boire  Peter Forsyth
Abstract:In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System Metastases in Tampa, Florida. The meeting included investigators from multiple academic centers and disciplines. A consensus summary of the progress and challenges in melanoma parenchymal brain metastases was published (Eroglu et al., Pigment Cell & Melanoma Research, 2019, 32, 458). Here, we will describe the current state of basic, translational, clinical research, and therapeutic management, for melanoma patients with leptomeningeal disease. We also outline key challenges and barriers to be overcome to make progress in this deadly disease.
Keywords:intrathecal therapy  leptomeningeal carcinomatosis  leptomeningeal disease  melanoma  neoplastic meningitis
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