Synthesis,Structural Characterization and Antimicrobial Evaluation of Ruthenium Complexes with Heteroaromatic Carboxylic Acids |
| |
| Authors: | Patrycja Rogala Grzegorz Czerwonka S&#x;awomir Micha&#x;kiewicz Maciej Hodorowicz Barbara Barszcz Agnieszka Jab&#x;o&#x;ska‐Wawrzycka |
| |
| Institution: | Patrycja Rogala,Grzegorz Czerwonka,Sławomir Michałkiewicz,Maciej Hodorowicz,Barbara Barszcz,Agnieszka Jabłońska‐Wawrzycka |
| |
| Abstract: | The antibacterial and antibiofilm activities of two new ruthenium complexes against E. coli, S. aureus, P. aeruginosa PAO1 (laboratory strain) and P. aeruginosa LES B58 (clinical strain) were evaluated. Complexes, mer‐RuIII(2‐bimc)3] ? H2O ( 1 ) and cis‐RuIVCl2(2,3‐pydcH)2] ? 4H2O ( 2 ), were obtained using aromatic carboxylic acid ligands, namely, 1H‐benzimidazole‐2‐carboxylic acid (2‐bimcH) and pyridine‐2,3‐dicarboxylic acid (2,3‐pydcH2). Compounds were physicochemically characterized using X‐ray diffraction, Hirshfeld surface analysis, IR and UV/VIS spectroscopies, as well as magnetic and electrochemical measurements. Structural characterization revealed that Ru(III) and Ru(IV) ions in the complexes adopt a distorted octahedral geometry. The intermolecular classical and weak hydrogen bonds, and π???π contacts significantly contribute to structure stabilization, leading to the formation of a supramolecular assembly. Biological studies have shown that the Ru complexes inhibit the growth of bacteria and biofilm formation by the tested strains and the complexes seem to be a potential as antimicrobial agents. |
| |
| Keywords: | antibiofilm activity cyclic voltammetry N O ligands ruthenium structural and spectroscopic studies |
|
|
