Synthesis and Antibacterial Evaluation of Mannich Bases Derived from 1,2,4‐Triazole |
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| Authors: | Agata Paneth,Nazar Trotsko,&#x ukasz Popio&#x ek,Agnieszka Grzegorczyk,Tomasz Krzanowski,Sara Janowska,Anna Malm,Monika Wujec |
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| Affiliation: | Agata Paneth,Nazar Trotsko,Łukasz Popiołek,Agnieszka Grzegorczyk,Tomasz Krzanowski,Sara Janowska,Anna Malm,Monika Wujec |
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| Abstract: | The series of novel Mannich bases were synthesized and evaluated for their in vitro antibacterial activity against Gram‐positive and Gram‐negative bacterial strains. The results showed that all compounds were less active than the drugs used as reference, but some of them had moderate potency against Staphylococcus epidermidis ATCC 12228 and Bacillus subtilis ATCC 6633. The presence of a phenyl ring in the position 4 of piperazine seems to be necessary for antibacterial activity in this class of compounds. |
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| Keywords: | 1,2,4-triazole Mannich base antibacterial activity biological activity |
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