Comparative Analysis of the Antibacterial Activity and HPLC Phytochemical Screening of the Brazilian Red Propolis and the Resin of Dalbergia ecastaphyllum |
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Authors: | Marcos da Silveira Regueira‐Neto,Saulo Relison Tintino,Ana Raquel Pereira da Silva,Maria do Socorro Costa,Cí cera Datiane de Morais Oliveira‐Tintino,Aline Augusti Boligon,Irwin R. A. Menezes,Valdir de Queiroz Balbino,Henrique Douglas Melo Coutinho |
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Abstract: | The aim of this study was to investigate the antibacterial activity of red propolis and resin and their association with standard antibiotics to evaluate possible differences of activity. We also submitted red propolis and the resin to a HPLC analysis to confirm the botanical origin. The extracts were tested against P. aeruginosa and S. aureus alone and in association with gentamicin and imipenem. The HPLC analysis identified seven compounds with six of them present in both substances. The lowest MIC values obtained in this study were observed against S. aureus. In general, MIC values showed to be lower for red propolis against all species tested in comparison to resin. Despite the synergistic behavior to be similar for both substances, we observed that inhibitory concentrations of drugs were lower when associated with red propolis in comparison to resin. |
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Keywords: | red propolis resin Dalbergia ecastaphyllum HPLC antibacterial activity |
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