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Synthesis and antimalarial activity of 2-methoxyprop-2-yl peroxides derivatives
Authors:Cointeaux Laure  Berrien Jean-François  Peyrou Viviane  Provot Olivier  Ciceron Liliane  Danis Martin  Robert Anne  Meunier Bernard  Mayrargue Joëlle
Affiliation:UPRES A 8076 BioCIS, Laboratoire de synthèse et conception des molécules d'intérêt thérapeutique, Faculté de Pharmacie, rue J.-B. Clément, F-92296 Chatenay Malabry Cedex, France.
Abstract:2-Methoxyprop-2-yl peroxides were synthesized and evaluated in vitro against Plasmodium falciparum. These acyclic artemisinin-related peroxides revealed moderate to good activity but were devoid of alkylating property towards the synthetic model of heme Mn(II)-TPP.
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