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Synthesis and antimalarial activity of 2-methoxyprop-2-yl peroxides derivatives |
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| Authors: | Cointeaux Laure Berrien Jean-François Peyrou Viviane Provot Olivier Ciceron Liliane Danis Martin Robert Anne Meunier Bernard Mayrargue Joëlle |
| Institution: | UPRES A 8076 BioCIS, Laboratoire de synthèse et conception des molécules d'intérêt thérapeutique, Faculté de Pharmacie, rue J.-B. Clément, F-92296 Chatenay Malabry Cedex, France. |
| Abstract: | 2-Methoxyprop-2-yl peroxides were synthesized and evaluated in vitro against Plasmodium falciparum. These acyclic artemisinin-related peroxides revealed moderate to good activity but were devoid of alkylating property towards the synthetic model of heme Mn(II)-TPP. |
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