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Progressive strenuous exercise induces the expression of HSP70 in rat skeletal muscles and myocardium |
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| Authors: | Young-Oh Shin Jae-Keun Oh Jun-Sang Bae Mi-Young Lee Jeong-Beom Lee Hun-Mo Yang Young-Ki Min Takaaki Matsumoto |
| Affiliation: | aDepartment of Sports Medicine, Korea National Sport University, Republic of Korea bThe Second Department of Physiology, Aichi Medical University, Nagakute, Aichi, Japan cDepartment of Physiology, College of Medicine, Soonchunhyang University, 336-1, Ssangyong-dong, Chenan-330-090, Korea |
| Abstract: | This study investigated the exercise-induced synthesis and accumulation of heat shock protein 70 (HSP70) after progressive strenuous exercise in rat soleus, plantaris, and myocardium. Sprague-Dawley rats were randomly assigned to one of six groups, one control group and five exercise groups, divided by intensity and duration of exercise. Skeletal muscles and heart were dissected immediately after last performance. The levels of HSP70 were analyzed by western blotting using a specific polyclonal antibody. Basal levels of HSP70 in soleus were the highest, and then followed by the myocardium and plantaris, in turn. Progressive strenuous exercise increased accumulation of HSP70 gradually in all three tissues. There were differences in patterns of increase among three tissues. |
| Keywords: | Heat shock protein 70 Exercise Muscle types Myocardium |
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