Neurohumoral effects of orphanin FQ/nociceptin: relevance to cardiovascular and renal function |
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| Authors: | Kapusta D R |
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| Affiliation: | Department of Pharmacology and Experimental Therapeutics, and the Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, 1901 Perdido Street, 70112, New Orleans, LA, USA. akapus@lsuhsc.edu |
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| Abstract: | Orphanin FQ/Nociceptin (OFQ/N) is a peptide whose structure resembles that of the endogenous opioid peptides (endorphins). OFQ/N and its receptor are distributed in neural tissue and brain regions involved in the regulation of pituitary hormone release. Functional studies have shown that this peptide evokes a unique pattern of cardiovascular and renal excretory responses. This review will focus on the neural and humoral effects of OFQ/N and how this peptide may participate in the regulation of cardiovascular and renal function. |
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