Ontogeny of Receptor Binding Sites for [3H]Glutamic Acid and [3H]Kainic Acid in the Rat Cerebellum |
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| Authors: | J. T. Slevin J. T. Coyle |
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| Affiliation: | Departments of Neuroscience, Pharmacology and Experimental Therapeutics, and Psychiatry and The Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, Maryland, U.S.A. |
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| Abstract: | The development of the specific binding sites for L-[3H]glutamic acid (KD = 370 nM) and for [3H]kainic acid (KD = 39 nM) was studied in the rat cerebellum. Specific binding at both sites remains low during the first week after birth but increases markedly during the second and third weeks after birth, when glutamatergic parallel fiber synaptogenesis occurs. The development of the kainate site lags behind that of the glutamate site, indicating their autonomy. |
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| Keywords: | l-[3H]Glutamic acid [3H]Kainic acid Receptor Binding sites Rat cerebellum |
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