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Structural determination of the capsular polysaccharide of Streptococcus pneumoniae type 19A (57)
Authors:Ewa Katzenellenbogen  Harold J. Jennings
Affiliation:Division of Biological Sciences, National Research Council of Canada, Ottawa, Ontario K1A OR6 Canada
Abstract:The structure of the Pneumococcus type 19A (57) capsular polysaccharide has been reinvestigated by using methylation analysis and n.m.r. spectroscopy. It is composed of residues of 2-acetamido-2-deoxy-d-mannose, d-glucose, l-rhamnose, and phosphate in the molar ratios of 1:1:1:1. The polysaccharide is linear, and is composed of these components in a repeating unit of the following structure.
/></figure>The type 19A polysaccharide (Na<sup>+</sup> salt) was depolymerized by heating it in water at 100°, conditions that also hydrolyzed the newly formed phosphoric monoesters.</td>
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