The small GTPase RAB37 functions as an organizer for autophagosome biogenesis |
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| Authors: | Ying Song Dantong Shang |
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| Affiliation: | Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, China |
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| Abstract: | Macroautophagy/autophagy is a catabolic process that is essential for cellular homeostasis. How autophagosomal vesicle forms in a spatio-temporally regulated manner remains elusive. Our recent study revealed that small GTPase, RAB37 (RAB37, member RAS oncogene family), functions as a key organizer of autophagosomal membrane biogenesis. RAB37 interacts with ATG5 (autophagy related 5) and promotes autophagosome formation by modulating ATG12–ATG5-ATG16L1 complex assembly. These findings provide new insights into autophagy regulation. |
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| Keywords: | autophagosome autophagy cell homeostasis GTPase membrane RAB proteins |
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