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Finding a ribophagy receptor
Authors:Meiyan Jin
Affiliation:1. Department of Molecular &2. Cell Biology, University of California, Berkeley, CA, USA
Abstract:Although ribophagy was demonstrated in budding yeast a decade ago, a specific receptor for this process has been unknown. Recently, a study revealed that NUFIP1 (nuclear FMR1 interacting protein 1) functions as a receptor for the selective degradation of ribosomes by starvation-induced autophagy in cultured mammalian cells. In addition to the identification of a selective autophagy receptor, this study suggests a strategy that can be adapted to the identification of additional novel receptor proteins.
Keywords:Autophagy  cargo  receptor  ribosomes  selective autophagy
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