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TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition
Authors:Santiago Lima  Kazuaki Takabe  Jason Newton  Kumar Saurabh  Megan M. Young  Andreia Machado Leopoldino
Affiliation:1. Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA USAslima@vcu.edu;3. Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA USA;4. Department of Surgery and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA USA;5. Department of Pharmacology, Department of Pediatrics, Penn State University College of Medicine, Hershey, PA, USA;6. Department of Clinical Analysis, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Riberi?o Preto, University of S?o Paulo, Ribeir?o Preto, SP, Brazil
Abstract:
Keywords:Apoptosis  autophagy  autophagic cell death  p53  TP53  S1P  SPHK1  SK1-I
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