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Fermentation of ginseng extracts by Penicillium simplicissimum GS33 and anti-ovarian cancer activity of fermented products |
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| Authors: | Yu Fu Zhenhao Yin Lunpeng Wu Chengri Yin |
| Institution: | 1. Department of Chemistry, Chemical Biology Research Center, Yanbian University, Gongyuan Road, Yanji, 133002, China 2. Department of Environmental Engineering, Chungnam National University, Daejeon City, 305-764, Korea 3. National Ginseng Products Quality Supervision Inspection Center, Yanji, 133000, Jilin, China |
| Abstract: | A total of 58 isolates of β-glucosidase-producing microorganisms were isolated from soil around the wild ginseng roots under forest using Esculin-R2A agar. Among these isolates, strain GS33 showed a strong ability to convert ginsenosides Rb1, Rb2, Rc, and Rd into F2, Rg3, C-K, and convert ginsenoside Rg1 into Rh1, and F1. Fermented ginseng products can inhibit ES-2 cells growth and the IC50 value was 0.73 mg ml?1. Phylogenetic analysis based on 16S rRNA gene sequences indicated that the strain GS33 belongs to the genus Penicillium and is most closely related to Penicillium simplicissimum (99 %). |
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