Myrtucommulone production by a strain of Neofusicoccum australe endophytic in myrtle (Myrtus communis) |
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Authors: | Rosario Nicoletti Pasquale Ferranti Simonetta Caira Gabriella Misso Maria Castellano Giuseppe Di Lorenzo Michele Caraglia |
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Institution: | 1. Consiglio per la Ricerca e la Sperimentazione in Agricoltura, Unità di Ricerca CAT, 84018, Scafati, Italy 2. Dipartimento di Agraria, Università di Napoli ‘Federico II’, 80055, Portici, Italy 3. Istituto di Scienze dell’Alimentazione, CNR, 83100, Avellino, Italy 4. Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università di Napoli, 80138, Naples, Italy 5. Sezione di Tumori Genitourinari e Centro Tumori Rari, Divisione di Oncologia Medica, Università di Napoli ‘Federico II’, 80100, Naples, Italy
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Abstract: | Myrtucommulones are acylphloroglucinol compounds reported from myrtle (Myrtus communis) and a few more plant species belonging in the Myrtaceae that have recently attracted the attention of pharmacologists for their anti-oxidant, anti-inflammatory and anti-tumor properties. An endophytic strain of Neofusicoccum australe recovered from a myrtle branch was selected based on the bioactivity of its culture extracts, and found to produce myrtucommulones A and D. A mixture of these compounds induced anti-proliferative effects on the human prostatic cancer cell lines DU145 and PC3, with a IC50 of respectively 4.64 and 3.11 mg/l. Along the lines of recent evidences of the ability by endophytic fungi to produce bioactive compounds originally extracted from their host plants, this is the first report of myrtucommulones as secondary metabolites of an endophytic fungal strain. The availability of a microbial strain to be cultured in vitro may provide access to more substantial amounts of these products for further investigations in view of their possible pharmaceutical use. |
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