Array synthesis of progesterone receptor antagonists: 3-aryl-1,2-diazepines |
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| Authors: | Wiethe Robert W Stewart Eugene L Drewry David H Gray David W Mehbob Abdul Hoekstra William J |
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| Institution: | Discovery Research, GlaxoSmithKline, Research Triangle Park, NC 27709-3398, USA. |
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| Abstract: | New non-steroidal chemotypes are required for the development of drugs targeting the steroid hormone receptors. The parallel array synthesis of 3-aryl-1,2-diazepines employing solid-supported reagents is described. The resulting compounds demonstrated high affinity binding to the progesterone receptor. |
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