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Parathyroid hormone effects on signaling pathways in endothelial cells vary with peptide concentration
Authors:Throckmorton Doug  Kurscheid-Reich Doris  Rosales Oscar R  Rodriguez-Commes Jose  Lopez Raquel  Sumpio Bauer  Zhong Qing  Ding Ke Hong  McCarthy Richard  Barrett Paula Q  Isales Carlos M
Institution:Institute for Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia, USA.
Abstract:We have previously reported that parathyroid hormone (PTH) has specific effects on a human umbilical vein endothelial cell line. Further studies were performed to characterize the signaling cascades initiated by PTH. We report that PTH induced the appearance of voltage sensitive calcium channels. Furthermore, PTH increased ceramide but not diacylglycerol content. Since elevations in Ca(2+)](i) and phospholipid turnover are signals for the activation of protein kinase C (PKC), the cells were screened for PKC isoforms. PTH induced a redistribution of the PKCepsilon to the particulate fractions of cell homogenates. In summary, PTH induced PKC translocation through a calcium-phospholipid pathway in an endothelial cell line.
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