Linkage analyses among five esterase loci in the laboratory rat (Rattus norvegicus) |
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Authors: | Junzo Yamada Hiroko Nikaido Sayuri Matsumoto |
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Affiliation: | (1) Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, 606 Kyoto, Japan |
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Abstract: | A cluster of esterase loci has been identified on a segment of a rat linkage group V; however, the linear order of all the loci has not been established. We estimated the recombination frequencies of two locus combinations among five esterase loci (Es-1, Es-2, Es-3, Es-4, and Es-Si) and the linear order of the loci by using three sets of backcross matings: (1) (K:W × IS) × IS, (2) (K:W × IS) × IS, and (3) (SHR × W) × W). The linear order was determined to be Es-1-Es-4-Es-2-Es-3-Es-Si, although the order of Es-2 and Es-4 remains tentative. The sexinfluenced esterase (Es-Si) was demonstrated to be distinct from Es-1 and was proposed to be Es-Si locus with two alleles of Es-Sia (positive) and Es-Sib (null).This work was partly supported by Grants-in-Aid for Scientific Research, No. 339020 (1978), from the Ministry of Education, Science and Culture, Japan. |
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Keywords: | rat esterase loci recombination frequency order of loci Es-Si locus |
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