GATA-6 is a novel transcriptional repressor of the human Tenascin-C gene expression in fibroblasts |
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| Authors: | Ghatnekar Angela Trojanowska Maria |
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| Affiliation: | Division of Rheumatology and Immunology, Medical University of South Carolina, CSB 912, SC 29425-2229, USA. |
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| Abstract: | In this study we show that GATA-6 is a novel repressor of TN-C gene expression. We demonstrated that overexpression of GATA-6 in fibroblasts inhibited basal levels, as well as markedly decreased IL-4- and TGF-beta-induced TN-C mRNA and protein levels. A GATA-6 response element was mapped to position -467 to -460 of the TN-C promoter. In addition, we showed that GATA-6 binds this site both in vitro and in vivo. |
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