Newly identified prions in budding yeast, and their possible functions |
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| Authors: | Crow Emily T Li Liming |
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| Institution: | Department of Molecular Pharmacology and Biological Chemistry, The Feinberg School of Medicine, Northwestern University, 320 East Superior Street, Chicago, IL 60611, USA. e-crow@northwestern.edu |
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| Abstract: | Yeast prions are atypical genetic elements that are transmitted as heritable protein conformations. PSI+], URE3], and PIN+] are three well-studied prions in the budding yeast, Saccharomyces cerevisiae. In the last three years, several additional prions have been reported in yeast, including SWI+], OCT+], MCA], GAR+], MOT3+], ISP+], and NSI+]. The growing number of yeast prions suggests that protein-based inheritance might be a widespread biological phenomenon. In this review, we summarize the characteristics of each prion element, and discuss their potential functional roles in yeast biology. |
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