| 不同来源血浆对静注人免疫球蛋白中抗-HBs、白喉抗体效价的影响 |
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| 引用本文： | 周海云,张安山,何彦林,梁艳,席三强,王剑霓.不同来源血浆对静注人免疫球蛋白中抗-HBs、白喉抗体效价的影响[J].微生物学免疫学进展,2008,36(1):40-42. |
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| 作者姓名： | 周海云 张安山 何彦林 梁艳 席三强 王剑霓 |
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| 作者单位： | 兰州生物制品研究所,兰州,730046 |
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| 摘 要： | 调查分析不同来源原料血浆对静注免疫球蛋白(IVIG)制品内的抗-HBs、白喉抗体效价的影响。选择6个单采血浆站,对其提供的血浆为原料制备的IVIG所含的抗-HBs抗体、白喉抗体效价进行了测定。检测结果显示,用A、B、C、D、E、F编号的6个相应血浆站采集的血浆为原料制备成IVIG其抗-HBs抗体(IU/g)效价分别为33.77、103.95、70.94、132.45、78.84、58.28;白喉抗体平均效价分别为5.17、7.36、4.26、7.67、10.14、9.24。6个单采血浆站间的IVIG制品中白喉抗体效价无明显差异,但抗-HBs效价却存有显著差异。
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| 关 键 词： | 原料血浆 供血浆者 乙肝疫苗 IVIG 抗-HBs |
| 文章编号： | 1005-5673(2008)01-0040-03 |
| 修稿时间： | 2007年5月31日 |
Effect of different source plasma on the titers of anti-HBs and diphtheria antibody in IVIG |
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| Abstract: | The effect of different source plasma on the titers of anti-HBs and diphtheria antibody in IVIG was investigated. Six plasmapheresis centers were selected,the immunization status of donators immunized with hepatitis B vaccine were analysed by statistics,and the antibody titers of anti-HBs and diphtheria in IVIG were detected. The results showed that the immunized level of donators vaccinated with hepatitis B vaccine is different in various plasmapheresis center. The antibody titer of anti-HBs(IU/g) and diphtheria(HAU/g) of IVIG made from six centers is 33.77/5.17,103.95/7.36,70.94/4.25,132.45/7.67,78.84/10.14 and 58.28/9.24 respectively. Except diphtheria antibody,the titers of anti-HBs are different along with the variance of immunized level of donors. |
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| Keywords: | Source plasma Plasma donors Hepatitis B vaccine IVIG Anti-HBs antibody |
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