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Evidence for linkage of a new region (11p14) to eczema and allergic diseases
Authors:Michel Guilloud-Bataille  Emmanuelle Bouzigon  Isabella Annesi-Maesano  Jean Bousquet  Denis Charpin  Frédéric Gormand  Joëlle Hochez  Jocelyne Just  Arnaud Lemainque  Nicole Le Moual  Régis Matran  Françoise Neukirch  Marie-Pierre Oryszczyn  Evelyne Paty  Isabelle Pin  Daniel Vervloet  Francine Kauffmann  Mark Lathrop  Florence Demenais  Marie-Hélène Dizier
Institution:1. INSERM U535, H?pital Paul Brousse, Batiment Leriche, B.P. 1000, 94817, Villejuif Cedex, France
2. Univ Paris-Sud, IFR69, Villejuif, France
3. INSERM, U794, Evry, France
4. Univ d’Evry, Evry, France
5. INSERM, U707, Paris, France
6. Univ Pierre et Marie Curie-Paris 6, Paris, France
7. Clinique des Maladies Respiratoires, INSERM U454, H?pital Arnaud de Villeneuve, Montpellier, France
8. Service de Pneumologie-Allergologie, H?pital Nord, Marseille, France
9. Service de Pneumologie, Centre Hospitalier Lyon-Sud, Pierre Benite, France
10. INSERM U436, Paris, France
11. Centre de Diagnostic et Traitement de l’Asthme, H?pital Trousseau, Paris, France
12. Centre National de Génotypage, Evry, France
13. INSERM, U780, Villejuif, France
14. Laboratoire d’Exploration Fonctionnelle, H?pital Calmette, Lille, France
15. INSERM U408, Paris, France
16. Service de Pneumologie Infantile, H?pital Necker, Paris, France
17. Département de Médecine Aigüe Spécialisée, CHU Michallon, Grenoble, France
18. Service de Pneumo-allergologie, H?pital Ste Marguerite, Marseille, France
Abstract:Asthma, allergic rhinitis (AR) and atopic dermatitis also called eczema are allergic co-morbidites, which are likely to depend on pleiotropic genetic effects as well as on specific genetic factors. After a previous genome-wide linkage screen conducted for asthma and AR in a sample of 295 French EGEA families ascertained through asthmatic subjects, the aim here was to search for genetic factors involved in eczema and more particularly the ones shared by the three allergic diseases using the same EGEA data. In this sake, eczema and phenotypes of “allergic disease” accounting for the joint information on the presence/absence of the three diseases were examined by linkage analyses using the maximum likelihood binomial method. A fine mapping was carried out in regions detected for potential linkage, followed by association studies using the family-based association test (FBAT). Evidence for linkage to 11p14 region was shown for “allergic disease” and eczema. Linkage was also indicated between eczema and 5q13 and between “allergic disease” and both 5p15 and 17q21 regions. Fine mapping supported the evidence of linkage to 11p14 and FBAT analyses showed the association between “allergic disease” and a marker located at the linkage peak on 11p14. Further investigations in this region will allow identifying genetic factor(s) which could have pleiotropic effect in the three allergic diseases.
Keywords:
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