Extensive genomic polymorphism within Mycobacterium avium |
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| Authors: | Semret Makeda Zhai Gary Mostowy Serge Cleto Cynthia Alexander David Cangelosi Gerard Cousins Debby Collins Desmond M van Soolingen Dick Behr Marcel A |
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| Affiliation: | McGill University Health Center, Montreal, Quebec, Canada. |
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| Abstract: | We have initiated comparative genomic analysis of Mycobacterium avium subspecies by DNA microarray, uncovering 14 large sequence polymorphisms (LSPs) comprising over 700 kb that distinguish M. avium subsp. avium from M. avium subsp. paratuberculosis. Genes predicted to encode metabolic pathways were overrepresented in the LSPs, and analysis revealed a polymorphism within the mycobactin biosynthesis operon that potentially explains the in vitro mycobactin dependence of M. avium subsp. paratuberculosis. |
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