A probable aculeacin A acylase from the Ralstonia solanacearum GMI1000 is N-acyl-homoserine lactone acylase with quorum-quenching activity |
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| Authors: | Chin-Nung Chen Chii-Jaan Chen Chen-Ting Liao Chia-Yin Lee |
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| Affiliation: | (1) Department of Agricultural Chemistry, National Taiwan University, Taipei, 10617, Taiwan, R.O.C |
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| Abstract: | Background The infection and virulence functions of diverse plant and animal pathogens that possess quorum sensing systems are regulated by N-acylhomoserine lactones (AHLs) acting as signal molecules. AHL-acylase is a quorum quenching enzyme and degrades AHLs by removing the fatty acid side chain from the homoserine lactone ring of AHLs. This blocks AHL accumulation and pathogenic phenotypes in quorum sensing bacteria. |
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