Genomic Organization, Complete Sequence, and Chromosomal Location of the Gene for Human Eotaxin (SCYA11), an Eosinophil-Specific CC Chemokine |
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| Authors: | Eduardo A Garcia-Zepeda Marc E Rothenberg Stanislawa Weremowicz Mindy N Sarafi Cynthia C Morton Andrew D Luster |
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| Institution: | aInfectious Disease Unit, Massachusetts General Hospital, Charlestown, Massachusetts, 02129;dDepartment of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, 02115;cBrigham and Women's Hospital, Department of Genetics, Boston, Massachusetts, 02115;bBrigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, 02115 |
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| Abstract: | Eotaxin is a CC chemokine that is a specific chemoattractant for eosinophils and is implicated in the pathogenesis of eosinophilic inflammatory diseases, such as asthma. We describe the genomic organization, complete sequence, including 1354 bp 5′ of the RNA initiation site, and chromosomal localization of the human eotaxin gene. Fluorescencein situhybridization analysis localized eotaxin to human chromosome 17, in the region q21.1–q21.2, and the human gene name SCYA11 was assigned. We also present the 5′ flanking sequence of the mouse eotaxin gene and have identified several regulatory elements that are conserved between the murine and the human promoters. In particular, the presence of elements such as NF-κB, interferon-γ response element, and glucocorticoid response element may explain the observed regulation of the eotaxin gene by cytokines and glucocorticoids. |
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