Role of the yiaR and yiaS genes of Escherichia coli in metabolism of endogenously formed L-xylulose |
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Authors: | Ibañez E Gimenez R Pedraza T Baldoma L Aguilar J Badia J |
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Institution: | Department of Biochemistry, School of Pharmacy, University of Barcelona, 08028 Barcelona, Spain. |
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Abstract: | Genes yiaP and yiaR of the yiaKLMNOPQRS cluster of Escherichia coli are required for the metabolism of the endogenously formed L-xylulose, whereas yiaS is required for this metabolism only in araD mutants. Like AraD, YiaS was shown to have L-ribulose-5-phosphate 4-epimerase activity. Similarity of YiaR to several 3-epimerases suggested that this protein could catalyze the conversion of L-xylulose-5-phosphate into L-ribulose-5-phosphate, thus completing the pathway between L-xylulose and the general metabolism. |
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