Possible participation of a free-radical lipid intermediate in the coupling of oxidation and phosphorylation

Data shown propose two regimes of lipid radicals and oxygen utilization realized in mitochondrial membranes. The first one--lipid peroxidation, i.e. interaction of lipid radical and oxygen is an empty step. In switching this regime to the functional one lipid peroxidation is inhibited. Setting L. -dependent coupling apparatus on phosphorylation in mitochondria takes place in the presence of ADP and Pi.