A MATHEMATICAL MODEL OF THE CELL CYCLE OF L5178Y |
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| Authors: | J. L.Roti Roti S. Okada |
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| Affiliation: | Departments of Experimental Radiology and Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York, U.S.A., and Department of Radiation Biophysics, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan;Department of Radiation Biophysics, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan |
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| Abstract: | Given the starting cell cycle age distribution and the growing conditions, the model developed through modification of Hahn's vector analysis predicts the age distribution of the population after a growth period. The model was able to simulate changes in growth and the per cent of cells in each stage of the cell cycle for cells growing in excess thymidine, in colcemid, in normal medium, and after successive treatments of these drugs, specifically the chemical synchronization method of L5178Y cells. |
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