The association of plasma peroxiredoxin 3 with insulin in pregnant women |
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Authors: | Li Wang Jun-Mei Hao Ai-Qun Yu Tian-Tian Li Ran-Ran Liu Lianqin Li Jingmin Li Xiaoyan Li |
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Affiliation: | 1. Department of Obstetrics, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, 264100, China;2. Department of Pathology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, 264100, China;3. Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China;4. Graduate School of Chinese Academy of Sciences, Beijing, 100049, China;5. Department of Reproductive Medicine, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, 264100, China;6. School of Basic Medical Sciences, Binzhou Medical University, Yantai, 264003, China |
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Abstract: | Peroxiredoxin 3 (PRX3) is predominantly located in mitochondria and plays a major role in scavenging hydrogen peroxide of mitochondria. In the present study, we detected plasma PRX3 in pregnant women receiving oral glucose tolerance test at 24–28 gestational weeks. Plasma PRX3 was significantly increased about 1?h later than insulin secretion. In vitro detection of PRX3 in mouse islet cells showed up-regulation by more than 2-fold at 1?h and reached its top at 2?h of glucose stimulation, and the PRX3 level in cultured mediums was concomitantly elevated in a glucose concentration-dependent manner. In addition, both fasting plasma insulin and PRX3 were significantly higher in the subjects of term pregnancy as compared to that at 24–28 gestational weeks, and there was a positive correlation between plasma PRX3 and insulin. Our results indicate that PRX3 plays an active role in the response to insulin release. The positive association of plasma PRX3 and insulin suggest PRX3 to be a potential indicator of high insulin resistance. |
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Keywords: | Peroxiredoxin Oxidative stress Gestational diabetes mellitus Insulin resistance |
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