Effects of PGF2α infusion on human cortisol biosynthesis |
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| Authors: | Anne Colston Wentz Georgeanna Seegar Jones Turner Bledsoe Laura Rocco |
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| Institution: | From the Department of Gynecology < Obstetrics and the Department of Medicine The Johns Hopkins University School of Medicine Baltimore, Maryland USA |
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| Abstract: | Intravenous administration of prostaglandin F2α to normal volunteers induced a three-fold increase in urinary cortisol output. Dexamethasone administration significantly inhibited the cortisol response, indicating that prostaglandin does not directly stimulate adrenal cortisol biosynthesis. Prostaglandin infusion appears to increase cortisol biosynthesis through stimulation of pituitary ACTH release. |
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