Analysis of fexofenadine in pharmaceutical formulations using tris(1,10‐phenanthroline)–ruthenium(II) peroxydisulphate chemiluminescence system in a multichip device |
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| Authors: | Haider A J Al Lawati Zeiyana M Al Dahmani Fakhr Eldin O Suliman Salma M Z Al Kindy Ali M Al‐Lawati |
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| Institution: | 1. Department of Chemistry, College of Science, Sultan Qaboos University, , Al‐Khod, 123 Oman;2. Department of Electrical and Computer Engineering, College of Engineering, Sultan Qaboos University, , Al‐Khod, 123 Oman |
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| Abstract: | A simple, rapid and sensitive method has been developed for the analysis of fexofenadine (FEX) in pharmaceutical formulations, using a tris(1,10‐phenanthroline)–ruthenium(II) Ru(phen)32+] peroxydisulphate chemiluminescence (CL) system in a multichip device. Various parameters that influence the CL signal intensity were optimized. These included pH, flow rates and concentration of reagents used. Under optimum conditions, a linear calibration curve in the range 0.05–5.0 µg/mL was obtained. The detection limit was found to be 0.001 µg/mL. The procedure was applied to the analysis of FEX in pharmaceutical products and was found to be free from interference from concomitants usually present in these preparations. Copyright © 2011 John Wiley & Sons, Ltd. |
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| Keywords: | microfluidics multichip fexofenadine chemiluminescence tris(1 10‐phenanthroline)– ruthenium(II) ammonium peroxodisulphate |
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