The conversion of 23,24-dinor-5-cholen-3β-ol to cortisol by the canine adrenal |
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Authors: | Alex.D. Tait |
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Affiliation: | Department of Investigative Medicine, University of Cambridge, Downing Street, Cambridge CB2 1QN, U.K. |
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Abstract: | An alternative pathway for steroidogenesis, via a sesterterpene, has been proposed. This communication presents evidence that the canine adrenal can utilise 23,24-dinor-5-cholen-3β-ol to biosynthesise cortisol.It has been proposed that steroid hormones could be biosynthesised by a pathway other than that through cholesterol, possibly by a sesterterpene pathway (1,2).The previous studies were carried out using bovine adrenal tissue. This communication extends these studies to include the canine adrenal gland. |
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