Design and biological activity of synthetic oligopeptides with Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) motifs for human osteoblast-like cell (MG-63) adhesion |
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| Authors: | Tae-Il Kim Jun-Hyeog Jang Yong-Moo Lee In-Cheol Ryu Chong-Pyoung Chung Soo-Boo Han Sang-Mook Choi Young Ku |
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| Institution: | (1) Department of Periodontology, College of Dentistry, Seoul National University, 28-1 Yongon-Dong, Chongno-Ku, Seoul, 110-749, South Korea;(2) Seoul National University, 28-1 Yongon-Dong, Chongno-Ku, Seoul, 110-749, South Korea |
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| Abstract: | A synthetic oligopeptide, composed of Arg-Gly-Asp (RGD) and its synergistic Pro-His-Ser-Arg-Asn (PHSRN) motifs and a six glycines (G6) linker, promoted human osteoblast-like cell (MG-63) adhesion, spreading and mitogen-activated protein kinase (MAPK) activity in a similar manner to a positive fibronectin control. This synthetic oligopeptide may therefore be a useful osteo-inductive material. |
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| Keywords: | fibronectin mitogen-activated protein kinase oligopeptides osteoblast-like cell |
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