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Design and biological activity of synthetic oligopeptides with Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) motifs for human osteoblast-like cell (MG-63) adhesion
Authors:Tae-Il Kim  Jun-Hyeog Jang  Yong-Moo Lee  In-Cheol Ryu  Chong-Pyoung Chung  Soo-Boo Han  Sang-Mook Choi  Young Ku
Institution:(1) Department of Periodontology, College of Dentistry, Seoul National University, 28-1 Yongon-Dong, Chongno-Ku, Seoul, 110-749, South Korea;(2) Seoul National University, 28-1 Yongon-Dong, Chongno-Ku, Seoul, 110-749, South Korea
Abstract:A synthetic oligopeptide, composed of Arg-Gly-Asp (RGD) and its synergistic Pro-His-Ser-Arg-Asn (PHSRN) motifs and a six glycines (G6) linker, promoted human osteoblast-like cell (MG-63) adhesion, spreading and mitogen-activated protein kinase (MAPK) activity in a similar manner to a positive fibronectin control. This synthetic oligopeptide may therefore be a useful osteo-inductive material.
Keywords:fibronectin  mitogen-activated protein kinase  oligopeptides  osteoblast-like cell
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