Enantioselective synthesis of a pyrrolo-benzothiadiazine derivative S 18986, a new AMPA receptor positive modulator |
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Authors: | P. Desos B. Serkiz P. Morain J. Lepagnol A. Cordi |
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Affiliation: | Institut de Recherches Servier, 11 rue des Moulineaux F92150, Suresnes, France |
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Abstract: | Enantioselective reduction of pyrrolo-benzothiadiazine 6 using various chiral reducing agents has been studied and led to efficient synthesis of 8 (S 18986) which was established to be of (S) configuration by single crystal X-ray diffraction analysis. S 18986 is a potent and selective AMPA positive modulator which displays total stereoselectivity, the (R) enantiomer being completely inactive. |
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